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1 article(s) from Jana, Poulami

Naphthalene diimide bis-guanidinio-carbonyl-pyrrole as a pH-switchable threading DNA intercalator

Poulami Jana,
Filip Šupljika,
Carsten Schmuck and
Ivo Piantanida

Beilstein J. Org. Chem. 2020, 16, 2201–2211, doi:10.3762/bjoc.16.185

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Scheme 1: DNA-targeting roles of the structural components incorporated in the design of the novel small mole...

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Scheme 2: Synthesis of compound 4. Conditions: a) mono-N-Boc-ethylenediamine, DMF, 90 °C; b) i) trifluoroacet...

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Figure 1: UV–vis titrations of compound 4 (c = 1.0 × 10⁻⁶ M), with ct-DNA at pH 7.0 (a) and at pH 5 (b). Inse...

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Figure 2: a) CD titration of ct-DNA (c = 3.0 × 10⁻⁵ M) with compound 4 at pH 7.0 (Na cacodylate buffer, I = 0...

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Figure 3: CD titration of poly(rA)–poly(rU) (c = 3.0 × 10⁻⁵ M) with compound 4 at a) pH 7.0 (Na cacodylate bu...

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Figure 4: CD titration of ds-DNAs (c = 3.0 × 10⁻⁵ M) with 4 for ratio r_[₄_{]/ [DNA]} = 0.4. Done at pH 5.0 (Na c...

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Figure 5: ITC experiments of poly(dAdT)–poly(dAdT) (c = 5.0 × 10⁻⁵ M) titrated with compound 4. Dots represen...

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Figure 6: AFM image of a) ct-DNA showing a fibre-like structure with a length of several micrometres; b) upon...

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Published 08 Sep 2020

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